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PhD Studentship at UCL: Development of molecular simulation methods for patient specific HIV drug treatment
Monday, 25 May 2009 11:54
The UCL Centre for Computational Science seeks to appoint a PhD student, funded by the UCLH/UCL Comprehensive Biomedical Research Centre (CBRC), to pursue an interdisciplinary, translational research project in the area of patient specific HIV drug treatment, using genotypic molecular simulation. The project will be supervised by Professor Peter Coveney (UCL Centre for Computational Science) and Professor Deenan Pillay (UCL Centre for Infection), and will involve:

  • Analysis/development of current and alternative methods for molecular binding affinity calculation, for HIV enzymes and their anti- retroviral ligands
  • Development of a HIV-1 integrase/inhibitor binding affinity calculation system
  • Establishment of links with experimentalists to facilitate validation of findings from simulations and provide information on novel mutations and anti-retroviral mutational pathways to be investigated
  • Incorporation of new/improved HIV drug/enzyme simulations into patient-specific a treatment evaluation and decision support pipeline.

    • The post requires a candidate with a strong ability in physical/ computational science, an affinity for and interest in biological sciences, and who is willing to integrate and progress their knowledge across these disciplines.

    Students will register during the 2009/10 academic year for a three year full-time MPhil/PhD degree, with an expected commencement date of 1st October 2009. Funding includes UK/EU tuition fees and a tax-free stipend equivalent to the MRC rate of £15,100 (in 2008/9). The position is available to both UK and EU applicants who must have, or expect to obtain, a very good first degree in a relevant subject (Chemistry, Physics or Virology, Computer Science) as a minimum qualification.

    To apply, please send a covering letter, application form and CV by email to Professor Peter Coveney (p.v.coveney(at)ucl.ac.uk), including the contact details of at least two academic referees. Application forms and details of the admissions process are available online at: http://www.ucl.ac.uk/prospective-students/graduate-study/applicationadmission/downloadable-applications.
    Informal inquiries may be made to Professor Coveney (p.v.coveney(at)ucl.ac.uk).
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