| Description | The Epidemiology of Transmission of Drug Resistant HIV-1
pp. 17-36 in HIV Sequence Compendium 2006/2007. Van de Vijver D, Wensing A, Boucher C (2007). Edited
by: Thomas Leitner T, Foley B, Hahn B, Marx P,
McCutchan F, Mellors J, Wolinsky S, Korber B.
Published by: Theoretical Biology and Biophysics
Group, Los Alamos National Laboratory, Los Alamos, NM.
LA-UR 07-4826
Introduction: The use of highly active antiretroviral therapy has dramatically reduced morbidity and mortality
among patients infected with HIV-1 (1,2). But the success of antiretroviral treatment is frequently limited
by the emergence of HIV drug resistance (3-5). Importantly, drug resistant viruses can be transmitted
to newly infected individuals (6-8). Transmission of drug resistant HIV is a major public health
concern, as it could lead to a situation in which no effective drugs are available for the treatment of HIV. (...) |